Vacation rentals in Panama City, Panama

Carefully selected & verified rentals in Panama City, Panama
Check-in
03Nov2025Select date
Check-out
04Nov2025Select date
Rooms and Guests2 Guests, 1 Room
Panama City boasts iconic spots like the Panama Canal, Casco Viejo, and the Amador Causeway. Enjoy vibrant nightlife at venues like Ocean Club Casino or relax on the sands of Playa Veracruz. You'll find amazing options from luxury hotels near the canal with stunning skyline views, to boutique hotels in Casco Viejo with unique architecture. This selection is carefully chosen based on excellent amenities and guest reviews. Book your stay early, as the best deals tend to go fast, especially during the Carnival season, and consider using public transport for easy city access.
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1-20 out of 426
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  • Price: high to low
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Amazinn Places Hotel Boutique Casa Marichu Panama City
Map5.1 km from City Centre400 m from Presidential Palace
FromUS$ 73 /nightSelect
Casa Lilia Airport Apartment Panama City
The largest option:
2 adults
1 bedroom
2 beds
Map14.7 km from City Centre700 m from Corredor Sur
FromUS$ 35 /nightSelect
Amazinn Places Boutique Casa Arias
MapCenter of historic old town100m
  • Outdoor swimming pool available
  • Rooms with full kitchen amenities
  • Pets allowed on-site
  • Swimming Pool
  • Private Bathroom
  • Kitchenette
Boutique hotel in the heart of Panama City's heritage
FromUS$ 46 /nightSelect
Yoo Panama
Map2.1 km from City Centre300 m from Coastal Beltway
FromUS$ 127 /nightSelect
Amazinn Places Rooftop And Jacuzzi IV
MapNear Canal Museum of Panama300m
  • Rooftop terrace with jacuzzi
  • Pets allowed for guests
  • Fully equipped kitchen available
  • Rooftop terrace
  • Hot tub
  • Air conditioning
Hotel featuring rooftop and jacuzzi in vibrant district
FromUS$ 111 /nightSelect
Amazinn Places Casco Viejo Casa Espanola
MapHistoric Casco Viejo neighborhood0.5km
  • Outdoor pool and jacuzzi available
  • Spacious rooms with fully equipped kitchen
  • Pet-friendly and non-smoking property
  • Outdoor pool
  • Jacuzzi
  • Fully equipped kitchen
Hotel with modern amenities in historic district
FromUS$ 110 /nightSelect
Habitaciones Privadas En Un Departamento Encantador
MapObarrio shopping center300m
  • Air-conditioned rooms with kitchen facilities
  • Shared lounge and terrace for guests
  • 24-hour front desk and tour assistance
  • Shared kitchen
  • Outdoor terrace
  • 24-hour reception
Hotel featuring private rooms in a charming setting
FromUS$ 26 /nightSelect
Small Loft At Casa Neuman, Casco Antiguo
4 adults
1 bedroom
2 beds
Map5.1 km from City Centre300 m from Presidential Palace
FromUS$ 107 /nightSelect
La Cresta By Wynwood House
Map2.1 km from City Centre800 m from Coastal Beltway
FromUS$ 51 /nightSelect
Amazinn Places Rooftop And Jacuzzi V
MapCasco Viejo historic quarter1km
  • Relaxing rooftop jacuzzi on-site
  • Air-conditioned rooms with terrace
  • Pet-friendly and no smoking
  • Rooftop Jacuzzi
  • Air Conditioning
  • Garden Access
Hotel featuring a rooftop jacuzzi in historic district
FromUS$ 132 /nightSelect
Bright 1Br With Pool In Casco Antiguo
MapClose to Canal Museum of Panama300m
  • Refreshing outdoor swimming pool
  • Well-equipped kitchen amenities
  • Located in historic Casco Viejo district
  • Swimming Pool
  • Kitchen Utensils
  • Outdoor Space
Hotel Offering Unique Stay in Historic Quarter
FromUS$ 106 /nightSelect
Casa Mercedes
Map5.0 km from City Centre500 m from Canal Museum of Panama
FromUS$ 47 /nightSelect
Maison Boheme - La Manzana Panama
Map5.1 km from City Centre700 m from Canal Museum of Panama
FromUS$ 61 /nightSelect
Best Location - Spacious And Fancy Apt
Map4.9 km from City Centre200 m from Presidential Palace
FromUS$ 250 /nightSelect
Amazinn Places Casco Viejo Pool And Rooftop XIII
MapHistoric Casco Viejo neighborhood100m
  • Outdoor swimming pool available
  • Rooftop terrace with views
  • Non-smoking rooms throughout
  • Outdoor Pool
  • Rooftop Terrace
  • Air Conditioning
Hotel with rooftop pool in historic Panama City
FromUS$ 67 /nightSelect
Amazinn Places Casco Viejo Pool And Rooftop VI
MapHistoric Casco Viejo neighborhood100m
  • Outdoor swimming pool available for guests
  • Well-equipped kitchen in each room
  • Pet-friendly environment for travelers
  • Rooftop pool
  • Air conditioning
  • Garden area
Hotel with rooftop pool in historic Panama City
FromUS$ 201 /nightSelect
Best Location - Unique And Charming Loft
MapRight in the center of the old town0.4km
  • Spacious rooms with garden views
  • Fully equipped kitchen with dishwasher
  • Flat-screen TV for entertainment
  • Air Conditioning
  • Flat-Screen TV
  • Balcony
Charming hotel in vibrant Casco Viejo district
FromUS$ 135 /nightSelect
Casa Love By Wynwood House
Map5.2 km from City Centre500 m from Presidential Palace
FromUS$ 54 /nightSelect
Amazinn Places Casco Viejo Relaxing Views And Sound Of The Sea
MapCultural heart of Casco Viejo200m
  • Beachfront property with sea views
  • Outdoor swimming pool access
  • Billiards tables for leisure
  • Outdoor pool
  • Beach access
  • Billiard tables
Hotel featuring stunning sea views and cultural access
FromUS$ 245 /nightSelect
Amazinn Places Rooftop And Jacuzzi VII
Map5.0 km from City Centre400 m from Presidential Palace
FromUS$ 115 /nightSelect

Flexible Price Range for Vacation Homes in Panama City

From cozy retreats to luxury villas – Find the ideal stay for every budget

⬆️ The highest price
US$ 837
⬇️ The lowest price
US$ 17
đź’¸ Average price for
Apartments
US$ 129

Top vacation homes in Panama City

Based on guest reviews from the past 12 months

Charming Boutique Retreats:
Amazinn Places Hotel Boutique Casa Marichu
Convenience Near the Airport:
Casa Lilia Airport
Stylish Coastal Apartments:
Boutique Apartments Panama Coco Del Mar
Scenic City Views:
Historical Vibes in Casco Viejo:
Modern Luxuries:
Yoo Panama
Penthouse Experiences:
Amazinn Places Rooftop And Jacuzzi

How to get to Panama City

Explore local transportation options with ease

Airports
Tocumen International (PTY)
Paitilla (PAC)

FAQs about Panama City rentals

Get answers to common questions and plan your adventure smoothly

Which neighborhoods in Panama City are best for vacation rentals near major attractions?
Casco Viejo and Avenida Balboa are popular neighborhoods for vacation rentals, both within 3 km of key landmarks like the Panama Canal and Biomuseo.
What vacation rentals in Panama City offer unique views?
Properties like Yoo Panama and Signature Point Bella Vista provide stunning city and ocean views, ideal for guests seeking picturesque scenery.
What are the best vacation rentals for couples in Panama City?
Couples may enjoy options like Casa La Costa By Wynwood House, which offer romantic settings and amenities, or the Luxurious Rooftop and Jacuzzi properties for a special stay.

Vacation Rentals Overview in Panama City

This guide provides essential insights into vacation rentals in Panama City, covering evaluated properties including prices, local fees, and proximity to key attractions for informed decision-making.

Typical nightly rates range from $50 to $200.

There are approximately 100 vacation rental properties available.

Peak travel seasons are December to April.

Local taxes and fees total around 10%.

Most rentals are within 3 miles of major attractions like Casco Viejo.

Check-in
03Nov2025Select date
Check-out
04Nov2025Select date
Rooms and Guests2 Guests, 1 Room