Vacation rentals in Panama City, Panama

Carefully selected & verified rentals in Panama City, Panama
Check-in
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Check-out
18Sept2025Select date
Rooms and Guests2 Guests, 1 Room
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1-20 out of 463
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  • Price: high to low
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Amazinn Places Hotel Boutique Casa Marichu Panama City
Map3.2 mi from City Centre400 yd from Presidential Palace
FromUS$ 73 /nightSelect
Lilia House 15 Minutos Aeropuerto Apartment Panama City
The largest option:
2 adults
1 bedroom
2 beds
Map9.2 mi from City Centre800 yd from Corredor Sur
FromUS$ 35 /nightSelect
Amazinn Places Boutique Casa Arias
MapCenter of historic old town100m
  • Outdoor swimming pool available
  • Rooms with full kitchen amenities
  • Pets allowed on-site
  • Swimming Pool
  • Private Bathroom
  • Kitchenette
Boutique hotel in the heart of Panama City's heritage
FromUS$ 46 /nightSelect
Yoo Panama
Map1.3 mi from City Centre300 yd from Coastal Beltway
FromUS$ 127 /nightSelect
Amazinn Places Rooftop And Jacuzzi IV
MapNear Canal Museum of Panama300m
  • Rooftop terrace with jacuzzi
  • Pets allowed for guests
  • Fully equipped kitchen available
  • Rooftop terrace
  • Hot tub
  • Air conditioning
Hotel featuring rooftop and jacuzzi in vibrant district
FromUS$ 78 /nightSelect
Amazinn Places Casco Viejo Casa Espanola
MapHistoric Casco Viejo neighborhood0.5km
  • Outdoor pool and jacuzzi available
  • Spacious rooms with fully equipped kitchen
  • Pet-friendly and non-smoking property
  • Outdoor pool
  • Jacuzzi
  • Fully equipped kitchen
Hotel with modern amenities in historic district
FromUS$ 110 /nightSelect
Casa Lourdes By Acomodocasco Viejo-Large Groups!
Map3.1 mi from City Centre300 yd from Presidential Palace
FromUS$ 82 /nightSelect
Habitaciones Privadas En Un Departamento Encantador
MapObarrio shopping center300m
  • Air-conditioned rooms with kitchen facilities
  • Shared lounge and terrace for guests
  • 24-hour front desk and tour assistance
  • Shared kitchen
  • Outdoor terrace
  • 24-hour reception
Hotel featuring private rooms in a charming setting
FromUS$ 27 /nightSelect
Small Loft At Casa Neuman, Casco Antiguo
4 adults
1 bedroom
2 beds
Map3.1 mi from City Centre400 yd from Presidential Palace
FromUS$ 107 /nightSelect
La Cresta By Wynwood House
Map1.3 mi from City Centre900 yd from Coastal Beltway
FromUS$ 51 /nightSelect
Amazinn Places Rooftop And Jacuzzi V
MapCasco Viejo historic quarter1km
  • Relaxing rooftop jacuzzi on-site
  • Air-conditioned rooms with terrace
  • Pet-friendly and no smoking
  • Rooftop Jacuzzi
  • Air Conditioning
  • Garden Access
Hotel featuring a rooftop jacuzzi in historic district
FromUS$ 54 /nightSelect
Bright 1Br With Pool In Casco Antiguo
MapClose to Canal Museum of Panama300m
  • Refreshing outdoor swimming pool
  • Well-equipped kitchen amenities
  • Located in historic Casco Viejo district
  • Swimming Pool
  • Kitchen Utensils
  • Outdoor Space
Hotel Offering Unique Stay in Historic Quarter
FromUS$ 106 /nightSelect
Boutique Apartments Panama Coco Del Mar
Map1.4 mi from City Centre900 yd from ATLAPA Conventions Center
FromUS$ 29 /nightSelect
Casa Mercedes
Map3.1 mi from City Centre500 yd from Canal Museum of Panama
FromUS$ 47 /nightSelect
Maison Boheme - La Manzana Panama
Map3.2 mi from City Centre700 yd from Canal Museum of Panama
FromUS$ 61 /nightSelect
Best Location - Spacious And Fancy Apt
Map3.0 mi from City Centre200 yd from Presidential Palace
FromUS$ 172 /nightSelect
Amazinn Places Casco Viejo Pool And Rooftop XIII
MapHistoric Casco Viejo neighborhood100m
  • Outdoor swimming pool available
  • Rooftop terrace with views
  • Non-smoking rooms throughout
  • Outdoor Pool
  • Rooftop Terrace
  • Air Conditioning
Hotel with rooftop pool in historic Panama City
FromUS$ 67 /nightSelect
Casa Love By Wynwood House
Map3.2 mi from City Centre600 yd from Presidential Palace
FromUS$ 54 /nightSelect
Amazinn Places Casco Viejo Relaxing Views And Sound Of The Sea
MapCultural heart of Casco Viejo200m
  • Beachfront property with sea views
  • Outdoor swimming pool access
  • Billiards tables for leisure
  • Outdoor pool
  • Beach access
  • Billiard tables
Hotel featuring stunning sea views and cultural access
FromUS$ 245 /nightSelect
Amazinn Places Rooftop And Jacuzzi VII
Map3.1 mi from City Centre400 yd from Presidential Palace
FromUS$ 40 /nightSelect

Flexible Price Range for Vacation Homes in Panama City

From cozy retreats to luxury villas – Find the ideal stay for every budget

⬆️ The highest price
US$ 837
⬇️ The lowest price
US$ 17
đź’¸ Average price for
Apartments
US$ 123

Top vacation homes in Panama City

Based on guest reviews from the past 12 months

Charming Boutique Retreats:
Amazinn Places Hotel Boutique Casa Marichu
Convenience Near the Airport:
Lilia House 15 Minutos Aeropuerto
Stylish Coastal Apartments:
Boutique Apartments Panama Coco Del Mar
Scenic City Views:
Historical Vibes in Casco Viejo:
Casa Lourdes By Acomodocasco Viejo-Large Groups!
Modern Luxuries:
Yoo Panama
Penthouse Experiences:
Amazinn Places Rooftop And Jacuzzi

How to get to Panama City

Explore local transportation options with ease

Airports
Tocumen International (PTY)
Paitilla (PAC)

FAQs about Panama City rentals

Get answers to common questions and plan your adventure smoothly

Which neighborhoods in Panama City are best for vacation rentals near major attractions?
Casco Viejo and Avenida Balboa are popular neighborhoods for vacation rentals, both within 3 km of key landmarks like the Panama Canal and Biomuseo.
What vacation rentals in Panama City offer unique views?
Properties like Yoo Panama and Signature Point Bella Vista provide stunning city and ocean views, ideal for guests seeking picturesque scenery.
What are the best vacation rentals for couples in Panama City?
Couples may enjoy options like Casa La Costa By Wynwood House, which offer romantic settings and amenities, or the Luxurious Rooftop and Jacuzzi properties for a special stay.

Vacation Rentals Overview in Panama City

This guide provides essential insights into vacation rentals in Panama City, covering evaluated properties including prices, local fees, and proximity to key attractions for informed decision-making.

Typical nightly rates range from $50 to $200.

There are approximately 100 vacation rental properties available.

Peak travel seasons are December to April.

Local taxes and fees total around 10%.

Most rentals are within 3 miles of major attractions like Casco Viejo.

Check-in
17Sept2025Select date
Check-out
18Sept2025Select date
Rooms and Guests2 Guests, 1 Room